Calgary is basically set up as a grid. To find most addresses you need to remember 2 things; 1) the city is divided into 4 quadrants, and 2) avenues run east-west and streets run north-south. For example, to find 1201 1st street SW, go to the southwest quadrant (lower left on a map) and find the intersection of 12th avenue and 1st street. Easy.
With so many people I know spending time in New York, it reminded me of one of the only frustrating things about navigating Manhattan; trying to find a specific address.