From: The Line it is Drawn #176: " Here’s a good one we haven’t done in quite a while (and in fact, I don’t think I’ve ever phrased it exactly like this before) – mash-up comic book characters with notable video games!"
shurwitt suggested: "Dr. Strange in the realm of Q*Bert!".
MechanisticMoth suggested: "Tintin and Lara Croft".